Development of Membrane Protein
For difficult-to-drug membrane protein targets with pronounced conformational heterogeneity (e.g., GPCRs, ion channels, and transporters), we provide end-to-end R&D services spanning conformationally preparation through Membrane Protein discovery, optimization, and functional validation. The workflow is compatible with structural biology methods such as cryo-EM and X-ray crystallography, as well as mechanistic pharmacology studies. For research use only.
Development of Membrane Protein Advantage
- End-to-end membrane-protein capability: Experienced in expression and purification of multiple membrane proteins, including GPCRs, supplying high-quality samples for functional and structural studies.
- Ready for SBDD: Atomic-level structures feed rational, structure-based drug discovery workflows.
Description for Development of Membrane Protein
Discovery and development around membrane-protein targets—especially GPCRs, the largest class of eukaryotic membrane receptors with ligand-induced conformational signaling via heterotrimeric G proteins.
What we do:
- Membrane-protein expression & purification for downstream function/structure.
- Cryo-EM workflow: Grid prep, vitrification, imaging, and 3D reconstruction—to deliver high-quality structures for SBDD.
Service Process of Development of Membrane Protein
- Scoping & design: Define target characteristics (e.g., GPCR class), intended application, and stabilization/solubilization strategy aligned to SBDD.
- Expression & purification: Produce and isolate the membrane protein to project-specific quality criteria.
- Cryo-EM sample & data: Grid preparation, vitrification, and electron-micrograph collection.
- Reconstruction & delivery: Image processing and 3D reconstruction; structural model/report packaged for structure-based design.
Why Choose Our Cutting-Edge Genomics Solutions And Laboratory Equipment?
Our cutting-edge genomics solutions, advanced laboratory instruments, and high-quality laboratory reagents and consumables are designed to provide all-round support for your scientific research and innovation. From DNA sequencing and molecular diagnostics to precision laboratory equipment, we provide reliable products that are widely used in academic, clinical and industrial fields. Our solutions are designed for modern scientific progress, helping laboratories improve efficiency and accuracy, and ensuring efficient advancement of scientific research and accurate results.
ChIP-seq
ChIP studies the interaction between DNA and proteins, and ChIP-seq is combined with next-generation sequencing to detect DNA sites in the genome that bind to specific transcription factors/histones, which is used to study the interaction between proteins and chromatin.
Genomics
Longlight has focused on molecular diagnosis and molecular biology, we has launched some NGS related instruments and reagent consumables, mainly Focused Ultrasonicator, been committed to promoting the development of genomics, to serve the human medical cause better.
Consumables and Kits
Longlight provides different types of precast agarose gel, nucleic acid scavenger, Qubit tube, nucleic acid extraction kits, and library preparation kits. In the meanwhile, all of these products can be widely used in basic scientific research, biopharmaceuticals and other application scenarios.
Contact Us
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